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mtSNP Database Search

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mtSAP 2D Structure
On the request of each client, locations of mtSAPs on the 2-dimensional structures of subunits encoded by mtDNA are displayed on the web page of the 2D Structure section of this mtSNP database. The 2D structures of NADH dehydrogenase subunits (ND1-6, ND4L), subunits of cytochrome c oxidase (CO1-3), and cytochrome b protein (Cytb) are based on the prediction of their hydrophobic transmembrane domains by the SOSUI system [Classification and Secondary Structure Prediction of Membrane Proteins by Mitaku Group, Department of Biotechnology, Tokyo University of Agriculture and Technology; sosui@proteome.bio.tuat.ac.jp; http://sosui.proteome.bio.tuat.ac.jp/sosuiframe0.html].
Coordinates of the amino acid residues were predicted by the SOSUI system. For ND1-6 and ND4L, as well as for subunits of ATP synthase (ATP6 and ATP8), the 3-dimensional structures of which are unknown, the amino (N) terminus of each subunit is located in the upper left corner. For the CO1, CO2, and CO3 subunits and the cytochrome b protein, the 3D structures of which are known for bovine enzymes, the orientation and folding of each subunit has been adjusted according to the crystal structure. The upper part corresponds to the inter-membrane space side; and the lower part, to the matrix side.
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