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mtSNP Database Search

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tRNA/rRNA 2D Structure
2D structure of tRNA
The structure of transfer RNA is displayed in the conventional cloverleaf structure by use of the program SstructView (http://smi-web.stanford.edu/projects/helix/sstructview/home.html). To display the location of a given nucleotide substitution, first select one of the tRNA genes in the scroll box and click "OK". Then a list of mtSNPs within the tRNA gene is displayed. Select one (or several) mtSNP by marking the corresponding checkbox, and then click the "OK" box. When the 2D structure of the tRNA molecule is displayed, click the "zoom in" button to enlarge the structure, or click the "zoom out" button to scale down the structure. The selected mtSNP is highlighted in blue color. To identify a nucleotide in the structure, move the cursor over the nucleotide, and then the nucleotide number (from 1 to 59-75 for each tRNA molecule) is displayed.

2D structure of rRNA
The secondary structure of the 12S ribosomal RNA molecule is displayed by use of the program SstructView (http://smi-web.stanford.edu/projects/helix/sstructview/home.html) according to the model of 12S rRNA (http://rrna.uia.ac.be/ssu/index.html) and that of 16S rRNA (http:// rrna.uia.ac.be/lsu/index.html) predicted by Dr. Jan Wuyts and Prof. Rupert De Wachter (Department of Biomedical Sciences, Antwerp University [UIA], Belgium). To display the location of a given nucleotide substitution, first select one of the rRNA genes in the scroll box and then click "OK". A list of mtSNPs within the rRNA gene is now displayed. Select one (or several) mtSNP by marking the corresponding checkbox, and then click the "OK" box. When the 2D structure of the rRNA molecule is displayed, click the "zoom in" button to enlarge the structure, or click the "zoom out" button to scale down the structure. The selected mtSNP is highlighted in blue color. To identify the position of a nucleotide in the structure, move the cursor over the nucleotide, and then the nucleotide number is displayed. 
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